Lithium Hydroxide → 2-(3,4-Dimethoxyphenyl)-2-hydroxyacetic acid

Participants

Reaction Steps

137B (890 mg, 3.9 mmol) was dissolved in THF (6 mL). 1M LiOH (6 mL) was added, and the reaction was stirred at rt for 1 h. The solvent was removed under reduced pressure, and water (10 mL) was added. The solution was acidified with 1 N HCl, then extracted with ethyl acetate (3×20 mL). The organic layer was concentrated to provide 137C (830 mg, 100%). LC-MS: 235.11 (M+Na)+.

Provenance & Evidence