反应详情

Trifluoromethanesulfonic anhydride (0.47 mL, 2.8 mmol) followed by triethylamine (0.42 mL, 3 mmol) was added to a cooled 0° C. solution of 5-ethyl-2-(3-methoxy-propyl)-phenol (0.45 g, 2.3 mmol). The reaction was stirred for 1 hour and then warmed to room temperature. The reaction was partitioned between 1 N HCl and EtOAc. The organic extracts were washed with bring, dried over Na2SO4 and concentrated to a black oil. 1H NMR (400 MHz, CDCl3): δ 1.24 (t, J=7.6 Hz, 3H), 1.89 (m, 2H), 2.65 (d, J=7.6 Hz, 2H), 2.75 (t, J=7.6 Hz, 2H), 3.35 (s, 3H), 3.40 (t, J=7.6 Hz, 2H), 7.07 (s, 1H), 7.14 (d, J=8.0 Hz, 1H), 7.23 (d, J=8.0 Hz, 1H).

1. customThe reaction was partitioned between 1 N HCl and EtOAc
2. washThe organic extracts were washed
3. dry with materialdried over Na2SO4
4. concentrationconcentrated to a black oil