HCID 58764221, compound → HCID 58764145, compound

Participants

Reaction Steps

The desired product was prepared analogously to example A(2), where 6-[2-cyclopentyl-4-(5-fluoro-4-hydroxymethyl-2-methoxy-phenyl)-2-hydroxy-but-3-ynyl]-2,2 dimethyl-[1,3]dioxin-4-one (1.28 g, 3.03 mmol) was substituted in place 6-[2-Cyclopentyl-4-(2-ethyl-5-methoxy-pyridin-4-yl)-2-hydroxy-but-3-ynyl]-2,2-dimethyl-[1,3]dioxin-4-one. Yield: 1.4 g, 38%. 1H NMR (400 MHz, CDCl3) δ: 1.37-1.49 (1H, m) 1.53-1.97 (9H, m) 2.53-2.6 (1H, m) 2.64-2.7 (1H, m) 2.75 (2H, s) 3.41 (2H, s) 3.79 (3H, s) 4.71 (2H, s) 6.79 (1H, d, J=9.85 HZ) 6.87 (1H, d, J=5.81 Hz). MS (ESI): 363 (M−H).

Provenance & Evidence