反应详情

The title compound was prepared analogously to example A(1), where 2-{4-[2-(2-Cyclopentyl-4,6-dioxo-tetrahydro-pyran-2-yl)-ethyl]-2-fluoro-phenyl}-2-methyl-propionitrile from step 3 below, was substituted in place of 6-[2-(3-Chloro-5-ethyl-4-methoxy-phenyl)-ethyl]-6-cyclopentyl-dihydro-pyran-2,4-dione and 2,5-Dimethyl-2H-[1,2,4]triazole-3-carbaldehyde was substituted instead of 5,7-Dimethyl-[1,2,4]triazolo[1,5-a]pyrimidine-2-carbaldehyde in that example. 1H NMR (300 MHz, DMSO-d6): δ 1.49-1.69 (m, 8H), 1.72 (s, 6H), 2.06 (s, 3H), 2.11 (s, 3H), 2.12-2.13 (m, 2H), 2.34-2.42 (m, 1H), 2.55-2.66 (m, 3H), 2.80 (d, J=17 Hz, 1H), 3.42-3.65 (m, 2H), 7.08-7.18 (m, 2H), 7.35-7.40 (m, 1H). Anal. Calcd. For C27H33FN4O3.0.25H2O: C, 66.85; H, 6.96; N, 11.55. Found: C, 66.88; H, 6.99; N, 11.60. ESIMS (MH+): 481.