反应详情

温度

90 °C

To a solution of 4-bromo-2-ethyl-benzoic acid (1.35 g, 5.89 mmol) in MeOH (40 mL) was added H2SO4 (1 drop). The mixture was stirred at 90° C. for 48 hours, at which time the volatiles were removed in vacuo. The residue was dissolved in Et2O, washed with satd NaHCO3 and brine, dried over MgSO4, and concentrated to a clear oil (1.01 g, 70%).

1. customwere removed in vacuo
2. dissolutionThe residue was dissolved in Et2O
3. washwashed with satd NaHCO3 and brine
4. dry with materialdried over MgSO4
5. concentrationconcentrated to a clear oil (1.01 g, 70%)