反应详情

6-Methylpyridine-2-carbonitrile (45.3 g, 0.384 mol) and methylhydrazine (94 mL, 5.30 mol) were mixed with ethanol (200 mL). The mixture was stirred at room temperature overnight, and then an additional portion (18 mL, 1.00 mol) of methylhydrazine was added, and the mixture was stirred for a further 16 h. The mixture was then evaporated to give 58.0 g of crude N′,6-dimethylpyridine-2-carbohydrazonamide (˜92% yield), which was used for the next stage of the synthesis without additional purification.

1. stirringthe mixture was stirred for a further 16 h
2. customThe mixture was then evaporated