HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 1-[1,1-Bis(methyloxy)ethyl]-4-tert-butylbenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Trimethyl orthoformate | HCID 9005 | — |
| Reactant | p-tert-Butylacetophenone | HCID 13669 | — |
| Catalyst | Tetra-n-butylammonium tribromide | HCID 23500184 | — |
| Product | 1-[1,1-Bis(methyloxy)ethyl]-4-tert-butylbenzene | HCID 68714107 | — |
Reaction Steps
To a stirred solution of 4′-tert-butylacetophenone (purcashed from Aldrich, 1.76 g, 10 mmol) in MeOH (1 mL) was added trimethyl orthoformate (1.97 g, 11 mmol) and tetrabutylammonium tribromide (48.2 mg, 0.1 mmol) successively. The same reaction procedure as described in Example 63A was performed to give the title compound (2.33 g) as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07622589B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-3c9f96d7886b4a3a99220f540f97a79b |
| Source note | uspto-grants-2009_11 |