Dimethylamine → 2-(Dimethylamino)-6-(trifluoromethyl)nicotinic acid

Participants

Reaction Steps

A mixture of 2-chloro-6-(trifluoromethyl)nicotinic acid (APOLLO, 2.5 g, 11.1 mmol) and 2M N-methylmethanamine in THF solvent (50 ml, 25 mmol) was stirred for 24 hours at room temperature according to J. Med. Chem., 2005, 48, 71. Then the reaction mixture-was evaporated in vacuo to give the title compound (2.5 g, 96%).

Provenance & Evidence