Chloroacetyl chloride → HCID 55298424, compound

Temperature

0 °C

To a mixture of (R)-2-amino-propan-1-ol (2.0 g, 26.6 mmol) in 150 mL of DCM at −40° C. under nitrogen atmosphere was added dropwise chloroacetyl chloride (2.3 mL, 29.2 mmol) in 60 mL of DCM. The mixture was gradually warmed to 0° C. and was stirred for 2 hours. After the removal of the solvents the residue was diluted with 50 mL of 1:1 ethyl acetate/hexane, stirred for 30 min and filtered. The filtrate was concentrated to afford 2-chloro-N-((R)-2-hydroxy-1-methyl-ethyl)-acetamide as a liquid.

1. customAfter the removal of the solvents the residue
2. additionwas diluted with 50 mL of 1:1 ethyl acetate/hexane
3. stirringstirred for 30 min
4. filtrationfiltered
5. concentrationThe filtrate was concentrated

ORD record

ord-453d25254100415e8c4f185997596c98

Source dataset

uspto-grants-2009_11

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07622583B2