Water → HCID 57942414, compound

Participants

Reaction Steps

A mixture of 4-chloro-N-[5-chloro-2-(4-oxo-piperidine-1-carbonyl)-pyridin-3-yl]-3-trifluoromethyl-benzenesulfonamide (20 mg), sodium borohydride (10 mg) in 1 mL of methanol was stirred at room temperature overnight. To the mixture was added water and the resulting mixture was extracted with ethyl acetate three times. The organic layer was washed with brine and dried. After the removal of solvents the residue was further purified by flash column (50% ethyl acetate in hexane) to afford the title compound as a white solid: 1H NMR: (CDCl3, ppm) δ 8.12 (d, 1 H), 8.09 (d, 1 H), 7.95 (dd, 1 H), 7.80 (d, 1 H), 7.62 (d, 1 H), 4.05 (m, 1 H), 3.88 (m, 1 H), 3.47 (m, 1 H), 3.36 (m, 1 H), 3.02 (m, 1 H), 1.94 (m, 1 H), 1.73 (m, 1 H), 1.58(m, 1 H), 1.48 (m, 2H); MS: (M+H)/z=498.0.

Provenance & Evidence