HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 3-Amino-4-methyl-1-(4-chlorobenzyl)-pyrazol-5-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | (4-Chlorobenzyl)hydrazine | HCID 3015209 | — |
| Reactant | beta-Amino-beta-ethoxymethacrylic acid ethyl ester | HCID 86734339 | — |
| Product | 3-Amino-4-methyl-1-(4-chlorobenzyl)-pyrazol-5-one | HCID 23334334 | — |
Reaction Steps
31.2 g of p-chlorobenzylhydrazine were added dropwise under nitrogen to a solution of 34.6 g of β-amino-β-ethoxymethacrylic acid ethyl ester and a pinch of p-toluenesulphonic acid in 200 ml of ethanol, whereupon the temperature rose from 21° C to 31° C. After standing overnight, the product which had precipitated was filtered off and recrystallized from ethanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04056533 |
| Source dataset | uspto-grants-1977_11 |
| ORD ID | ord-eaedfe87a9a14072a8d984a4805e981a |
| Source note | uspto-grants-1977_11 |