Sulfuric Acid → HCID 20310624, compound

HRID 1438720Notes

Reaction equation

HRID 1438720 reaction equation
[C:1]([C:4]1[CH:5]=[C:6]2[N:12]([CH:13]=1)[CH:11]=[CH:10][C:9]1[CH:14]=[CH:15][CH:16]=[CH:17][C:8]=1[C:7]2=[O:18])(=[O:3])N.S(=O)(=O)(O)[OH:20].N([O-])=O.[Na+]>O>[C:1]([C:4]1[CH:5]=[C:6]2[N:12]([CH:13]=1)[CH:11]=[CH:10][C:9]1[CH:14]=[CH:15][CH:16]=[CH:17][C:8]=1[C:7]2=[O:18])([OH:20])=[O:3]

Participants

5

Reactant 3

HCID 1118Sulfuric AcidHCID 20310613HCID 20310613, compoundHCID 23668193Sodium Nitrite

Product 1

HCID 20310624HCID 20310624, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To 2-carbamoyl-11H-pyrrolo[2,1-b][3]benzazepine-11-one (27 g., 0.112 moles) in 300 ml. of 50% sulfuric acid maintained at 50° C. is added slowly 25 g. of sodium nitrite in 75 ml. of water. At the end of the addition, the solid is filtered, washed with water and air-dried to yield 2-carboxy-11H-pyrrolo[2,1-b] [3]benzazepine-11-one.

Workup

  1. additionis added slowly 25 g
  2. additionAt the end of the addition
  3. filtrationthe solid is filtered
  4. washwashed with water
  5. customair-dried

Sources & evidence

ORD record
ord-a8ba39a0f4d2436d92af07afe8cc2019
Source dataset
uspto-grants-1977_11
Patent number
US04056536

Reaction notes

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