Hydrochloric Acid → 4H-1,3-Benzodioxin-2-methanamine, 6-chloro-N-(1-methylethyl)-4-phenyl-, hydrochloride, cis-

Participants

Reaction Steps

A solution of cis-6-chloro-4-phenyl-N-(2-propyl)-1,3-benzodioxan-2-carboxamide (6.6 g, 20.0 mmoles) in 400 ml of anhydrous THF was treated with 80 ml (80 mmoles) of diborane in THF solution (1M as BH3) and the reaction mixture was worked up essentially as described in Example 5b. The oily amine was converted to the hydrochloride in anhydrous ether; 7.4 g of colorless powder was obtained. Recrystallization from absolute EtOH gave 5.96 g (84%) of colorless crystals; mp 224.5°-225.5°.

Provenance & Evidence