Triethylamine → HCID 22799972, compound

Participants

Reaction Steps

cis-6-Chloro-4-phenyl-N-(3-dimethylaminopropyl)-1,3-benzodioxan-2-carboxamide hydrochloride (1.06 g, 2.59 mmole), triethylamine (0.526 g., 5.2 mmole) and 30% Pd on Celite (0.6 g) were mixed in abs EtOH (200 ml) and hydrogenated in a Parr apparatus for 21/2 hrs. (14 lb H2 uptake). Workup and treatment with HClg in the usual manner (see example 12) gave the product (0.7 g., 71.8% mp 178°-186° d) after recrystallization from i-PrOH:Et2O.

Provenance & Evidence