Diethyl Ether → 3-Bromo-1-(4-fluorophenyl)-1-phenylpropan-2-one

Participants

Reaction Steps

Bromine (14.85g) in acetic acid (200 ml.) was added dropwise to a solution of 1-p-fluorophenyl-1-phenylpropan-2-one (20.1g.) in acetic acid (200 ml.) at 60° - 70°. After 30 minutes, the reaction mixture was poured on to ice. Isolation through ether in the usual manner gave crude 3-bromo-1-p-fluorophenyl-1-phenyl-propan-2-one (28g) which was converted by the procedures described in Example 1 to 3-(N-Benzyl,N-methylamino)-1-p-fluorophenyl-1-phenyl-propan-2-ol (38%), m.p. 61° - 62°.

Provenance & Evidence