HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylamine → 3-Dimethylamino-1-p-fluorophenyl-1-phenyl-propan-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | 3-Bromo-1-(4-fluorophenyl)-1-phenylpropan-2-one | HCID 12549035 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 3-Dimethylamino-1-p-fluorophenyl-1-phenyl-propan-2-one | HCID 20309066 | — |
Reaction Steps
Dimethylamine in ethanol (30 ml s of 33% solution ) was added to a solution of 3-bromo-1-p-fluorophenyl-1-phenyl-propan-2-one (13g) in dry ether. After 45 minutes, the reaction mixture was extracted with dilute hydrochloric acid and ether. Basification of the acid extract and subsequent isolation through ether in the usual manner gave 3-dimethylamino-1-p-fluorophenyl-1-phenyl-propan-2-one isolated as the hydrochloride (5.8g., 53%), m.p. 210° - 220°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04056630 |
| Source dataset | uspto-grants-1977_11 |
| ORD ID | ord-b669e8a176724822ad9b31507a442922 |
| Source note | uspto-grants-1977_11 |