Phenyl chloroformate → HCID 53934473, compound

Participants

Reaction Steps

Under a nitrogen atmosphere, a mixture of 45.0 g of 5-amino-4-cyano-3-(ethylthio)isothiazole and 47.0 g of phenyl chloroformate in 175 ml of dried toluene was heated under reflux for 16 hours; thin-layer chromatography indicated the reaction to be complete. The reaction mixture was cooled to 10°, and the solid collected by filtration to obtain 66.2 of phenyl (4-cyano-3-(ethylthio)-5-isothiazolyl)carbamate, m.p. 223°-225° after recrystallization from acetic acid. The nmr spectrum was consistent with the assigned structure.

Provenance & Evidence