Dimethylamine → N'-[4-Cyano-3-(ethylsulfanyl)-1,2-thiazol-5-yl]-N,N-dimethylurea
Reaction equation
[C:1]([C:3]1[C:4]([S:18][CH2:19][CH3:20])=[N:5][S:6][C:7]=1[NH:8][C:9](=[O:17])OC1C=CC=CC=1)#[N:2].[CH3:21][NH:22][CH3:23]>>[CH3:21][N:22]([CH3:23])[C:9]([NH:8][C:7]1[S:6][N:5]=[C:4]([S:18][CH2:19][CH3:20])[C:3]=1[C:1]#[N:2])=[O:17]Participants
3
Procedure
Two samples (30.9 g each) of phenyl (4-cyano-3-(ethylthio)-5-isothiazolyl)carbamate were reacted with dimethylamine (9.13 g per batch) in the manner described in Example IV B. The reaction mixtures from the two runs were combined and processed as in IV B to give 41.5 g of 1,1-dimethyl-3-(4-cyano-3-(ethylthio)-5-isothiazolyl)urea, m.p. 198° after recrystallization from ethanol. The nmr spectrum was consistent with the assigned structure.
Sources & evidence
- ORD record
- ord-be22200e198e44f689ae6c9a90759e32
- Source dataset
- uspto-grants-1977_11
- Patent number
- US04057416
Reaction notes
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