Sulfuric Acid → HCID 18550614, compound

Participants

Reaction Steps

A stirred solution of 4.0 g of 1-methyl-3-(4-cyano-3-(ethylthio)-5-isothiazolyl)urea in 6 ml of concentrated sulfuric acid was heated at 160° for 1.5 hours. After this time the reaction mixture was poured into 120 ml of ice-water, and this mixture was stirred for 45 minutes. The white precipitate was collected by filtration. The solid was recrystallized from ethanol to give 4.0 grams of 1-methyl-3-(4-carbamoyl-3-(ethylthio)-5-isothiazolyl)urea, m.p. 205°. The nmr spectra was consistent with the assigned structure.

Provenance & Evidence