Sulfuric Acid → HCID 21399278, compound

Participants

Reaction Steps

A mixture of 8.8 g of 1-methyl-3-(4-cyano-3-(ethylsulfonyl) -5-isothiazolyl)urea and 10 ml of concentrated sulfuric acid was heated at 100° for 2.25 hours, then poured into 150 ml of ice-water. The solid was isolated and recrystallized from acetic acid-water to give 2.8 g of 1-methyl-3-(4-carbamoyl-3-(ethylsulfonyl)-5-isothiazolyl)urea, m.p. 219°-220°. An additional 2.2 g was obtained by concentrating the mother liquor from the recrystallization. The nmr and ir spectra were consistent with the assigned structure.

Provenance & Evidence