Dimethylformamide → Saccharin

Participants

Reaction Conditions

Reaction Steps

Into a four necked flask equipped with a stirrer, a thermometer, a condenser and a phosgene inlet, were charged 24.0 g (0.1 mole) of the monopotassium salt of o-sulfobenzoic acid ##STR10## 150 ml of toluene and 0.22 g (0.003 mole) of dimethylformamide. The mixture was stirred at 80° C and 23 g of phosgene were introduced into the mixture over 4 hours. The reaction was continued by maintaining the temperature at 80° - 90° C under refluxing with stirring for 3 hours. After the reaction, nitrogen gas was injected into the mixture to remove excess phosgene. The reaction mixture was filtered to remove potassium chloride and the filtrate was condensed and a colorless condensate was obtained.

Provenance & Evidence