Ammonia → HCID 12557669, compound

HRID 1438886Notes

Reaction equation

HRID 1438886 reaction equation
[NH2:1][C:2]1[C:3](=O)[C:4]([O:9][C:10]2C=CC=CC=2)=[CH:5][CH:6]=[CH:7][CH:8]=1.N.C[OH:19]>>[NH2:1][C:2]1[C:8](=[O:19])[CH:7]=[CH:6][CH:5]=[C:4]([O:9][CH3:10])[CH:3]=1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 887MethanolHCID 12557652HCID 12557652, compound

Product 1

HCID 12557669HCID 12557669, compound

Conditions

Temperature
80 °C

Procedure

A solution of 2,4-dimethoxy-2,4,6-cycloheptatrien-1-one [described above in (b),2.4 g] in methanol (70 ml) is cooled to -25° C and saturated with ammonia gas. The solution is heated in a pressure bottle at 80° C for 4 hours and cooled to -70° C. The pressure bottle is opened and the solvent is evaporated to give 2-amino-4-methoxy-2,4,6-cycloheptatrien-1-one.

Workup

  1. temperaturecooled to -70° C
  2. customthe solvent is evaporated

Sources & evidence

ORD record
ord-63a56daa2f7b4b529f2878cb67db3815
Source dataset
uspto-grants-1977_11
Patent number
US04057556

Reaction notes

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