Ammonia → HCID 12557679, compound

HRID 1438889Notes

Reaction equation

HRID 1438889 reaction equation
CO[C:3]1[C:4](=[O:22])[C:5]([N:10]([S:12]([C:15]2[CH:20]=[CH:19][C:18]([CH3:21])=[CH:17][CH:16]=2)(=[O:14])=[O:13])[CH3:11])=[CH:6][CH:7]=[CH:8][CH:9]=1.[NH3:23]>CO>[NH2:23][C:3]1[C:4](=[O:22])[C:5]([N:10]([S:12]([C:15]2[CH:20]=[CH:19][C:18]([CH3:21])=[CH:17][CH:16]=2)(=[O:14])=[O:13])[CH3:11])=[CH:6][CH:7]=[CH:8][CH:9]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 12557676HCID 12557676, compound

Product 1

HCID 12557679HCID 12557679, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
80 °C

Procedure

A solution at -25° C of 2-methoxy-7-[N-[(4-methylphenyl)sulfonyl]-N-methylamino]-2,4,6cycloheptatrien-1-one (described above, 4.0 g) in methanol (40 ml) is saturated with ammonia gas and heated in a pressure bottle at 80° C for 4 hours. The solution is cooled to -70° C, the bottle is opened and the solvent is evaporated to yield 2-amino-7-[N-[(4-methylphenyl)sulfonyl]-N-methylamino]-2,4,6-cycloheptatrien-1-one, mp 221°-222° C.

Workup

  1. customat -25° C
  2. temperatureThe solution is cooled to -70° C
  3. customthe solvent is evaporated

Sources & evidence

ORD record
ord-c77f6ac47bd249339b9b283094416f99
Source dataset
uspto-grants-1977_11
Patent number
US04057556

Reaction notes

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