Sodium Carbonate → HCID 12557682, compound

HRID 1438890Notes

Reaction equation

HRID 1438890 reaction equation
[NH2:1][C:2]1[C:3](=[O:21])[C:4]([N:9](S(C2C=CC(C)=CC=2)(=O)=O)[CH3:10])=[CH:5][CH:6]=[CH:7][CH:8]=1.C(=O)([O-])[O-].[Na+].[Na+]>S(=O)(=O)(O)O>[NH2:1][C:2]1[C:3](=[O:21])[C:4]([NH:9][CH3:10])=[CH:5][CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 10340Sodium CarbonateHCID 12557679HCID 12557679, compound

Product 1

HCID 12557682HCID 12557682, compound

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

A solution of 2-amino-7-[N-[(4-methylphenyl)sulfonyl]-N-methylamino]-2,4,6-cycloheptatrien-1-one [described in Example 9 (b), 2.53 g] in conc. sulfuric acid (25 ml) is heated at 75° C for 1 hour and added to ice. The ice-mixture is neutralized with sat. sodium carbonate solution and extracted with chloroform. The organic extract is dried over sodium sulfate and evaporated to give 2-amino-7-methylamino-2,4,6-cycloheptatrien-1-one.

Workup

  1. customis heated at 75° C for 1 hour
  2. additionadded to ice
  3. extractionextracted with chloroform
  4. extractionThe organic extract
  5. dry with materialis dried over sodium sulfate
  6. customevaporated

Sources & evidence

ORD record
ord-ad6963aef6a5471ca71051eb420f8f34
Source dataset
uspto-grants-1977_11
Patent number
US04057556

Reaction notes

Loading…