Methanol → HCID 54313851, compound

HRID 1438933Notes

Reaction equation

HRID 1438933 reaction equation
[OH-:1].[Na+].[Cl:3][C:4]1[CH:23]=[CH:22][CH:21]=[CH:20][C:5]=1[CH2:6][C:7]1[CH:8]=[C:9]2[C:13](=[CH:14][C:15]=1[OH:16])[CH:12]([C:17]([OH:19])=[O:18])[CH2:11][CH2:10]2.[CH3:24]O>>[CH3:24][O:18][C:17]([CH:12]1[C:13]2[C:9](=[CH:8][C:7]([C:6](=[O:1])[C:5]3[CH:20]=[CH:21][CH:22]=[CH:23][C:4]=3[Cl:3])=[C:15]([OH:16])[CH:14]=2)[CH2:10][CH2:11]1)=[O:19]

Participants

4

Reactant 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 21399671HCID 21399671, compound

Product 1

HCID 54313851HCID 54313851, compound

Procedure

Analogously to the description in Example 2, 8.7 g of 5-(o-chlorobenzoyl)-6-hydroxy-indane-1-carboxylic acid methyl ester and 27 ml of 2 N sodium hydroxide solution in 100 ml of methanol give 5-(o-chlorobenzyl)-6-hydroxy-indane-1-carboxylic acid of melting point 188°-190° C (from ethyl acetate-petroleum ether).

Sources & evidence

ORD record
ord-74f9c4cf9a0349a795b382b98e39c5e8
Source dataset
uspto-grants-1977_11
Patent number
US04057573

Reaction notes

Loading…