反应详情

18 g of finely powdered aluminum chloride are added in portions of a solution of 8 g of indane-1-carboxylic acid methyl ester and 8.2 g of benzoyl chloride in 100 ml of carbon disulphide, whilst stirring in an anhydrous atmosphere. After completion of the addition, the reaction mixture is heated for 2 hours to the reflux temperature. It is then allowed to cool to room temperature, poured onto a mixture of 100 g of ice and 50 ml of concentrated hydrochloric acid and extracted with twice 100 ml of ether. The organic phases are combined, washed with twice 100 ml of water, dried over sodium sulphate and evaporated in vacuo. Distillation of the evaporation residue in a high vacuum gives 6-benzoyl-indane-1-carboxylic acid methyl ester in the fraction boiling at 165°-170° C (0.5 mm).

1. additionAfter completion of the addition
2. temperaturethe reaction mixture is heated for 2 hours to the reflux temperature
3. extractionextracted with twice 100 ml of ether
4. washwashed with twice 100 ml of water
5. dry with materialdried over sodium sulphate
6. customevaporated in vacuo
7. distillationDistillation of the evaporation residue in a high vacuum