Methanol → 6-Benzoyl-indane-1-carboxylic acid methyl ester

HRID 1438937Notes

Reaction equation

[OH-].[Na+].[C:3]([C:11]1[CH:19]=[C:18]2[C:14]([CH2:15][CH2:16][CH:17]2[C:20]([OH:22])=[O:21])=[CH:13][CH:12]=1)(=[O:10])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[CH3:23]O>>[CH3:23][O:21][C:20]([CH:17]1[C:18]2[C:14](=[CH:13][CH:12]=[C:11]([C:3](=[O:10])[C:4]3[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=3)[CH:19]=2)[CH2:15][CH2:16]1)=[O:22]

Participants

Reactant 3

HCID 887Methanol

HCID 14798Sodium Hydroxide

HCID 123185116-Benzoyl-2,3-dihydro-1H-indene-1-carboxylic acid

Product 1

HCID 536621386-Benzoyl-indane-1-carboxylic acid methyl ester

Procedure

Analogously to the description in Example 2, 13 g of 6-benzoyl-indane-1-carboxylic acid methyl ester and 75 ml of 2 N sodium hydroxide solution in 500 ml of methanol give 6-benzoyl-indane-1-carboxylic acid of boiling point 200° C/0.04 mm Hg as a yellowish, viscous oil.

Sources & evidence

ORD record: ord-29e3bfd61d0c42338e629e365ba05279
Source dataset: uspto-grants-1977_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04057573

Reaction notes

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