Methanol → HCID 54114833, compound

HRID 1438940Notes

Reaction equation

HRID 1438940 reaction equation
[OH-].[Na+].[C:3]([C:11]1[CH:12]=[C:13]2[C:17](=[CH:18][C:19]=1[OH:20])[CH:16]([CH2:21][C:22]([OH:24])=[O:23])[CH2:15][CH2:14]2)(=[O:10])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[CH3:25]O>>[CH3:25][O:23][C:22](=[O:24])[CH2:21][CH:16]1[C:17]2[C:13](=[CH:12][C:11]([C:3](=[O:10])[C:4]3[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=3)=[C:19]([OH:20])[CH:18]=2)[CH2:14][CH2:15]1

Participants

4

Reactant 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 23457882HCID 23457882, compound

Product 1

HCID 54114833HCID 54114833, compound

Procedure

Analogously to the description in Example 2, 7.5 g of 5-benzoyl-6-hydroxy-indane-1-acetic acid methyl ester and 50 ml of 2 N sodium hydroxide solution in 300 ml of methanol give 5-benzoyl-6-hydroxy-indane-1-acetic acid of melting point 148°-150° C (from ether-petroleum ether).

Sources & evidence

ORD record
ord-bc1c7a489aa84253aec077731fd6b265
Source dataset
uspto-grants-1977_11
Patent number
US04057573

Reaction notes

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