Ethanol → 6-Hydroxy-7-benzoyl-1,2,3,4-tetrahydro-1-naphthylacetic acid ethyl ester
Reaction equation
[OH-].[Na+].[OH:3][C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][C:13]=1[C:14](=[O:21])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[CH:10]([CH2:22][C:23]([OH:25])=[O:24])[CH2:9][CH2:8][CH2:7]2.[CH2:26](O)[CH3:27]>>[CH2:26]([O:24][C:23](=[O:25])[CH2:22][CH:10]1[C:11]2[C:6](=[CH:5][C:4]([OH:3])=[C:13]([C:14](=[O:21])[C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[CH:12]=2)[CH2:7][CH2:8][CH2:9]1)[CH3:27]Participants
4
Procedure
Analogously to the description in Example 2, 5.5 g of 6-hydroxy-7-benzoyl-1,2,3,4-tetrahydro-naphthalene-acetic acid ethyl ester and 20 ml of 2 N sodium hydroxide solution in 250 ml of ethanol give 6-hydroxy-7-benzoyl-1,2,3,4-tetrahydro-1-naphthylacetic acid in the form of yellow crystals of melting point 118°-120° C (from ether-petroleum ether).
Sources & evidence
- ORD record
- ord-6dadc0ce3ae741e8949088a5dbf4856e
- Source dataset
- uspto-grants-1977_11
- Patent number
- US04057573
Reaction notes
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