Methanol → HCID 54224008, compound

HRID 1438944Notes

Reaction equation

HRID 1438944 reaction equation
[OH-].[Na+].[CH3:3][C:4]1([C:23]([OH:25])=[O:24])[C:12]2[C:7](=[CH:8][C:9]([C:15](=[O:22])[C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)=[C:10]([O:13][CH3:14])[CH:11]=2)[CH2:6][CH2:5]1.[CH3:26]O>>[CH3:26][O:24][C:23]([C:4]1([CH3:3])[C:12]2[C:7](=[CH:8][C:9]([C:15](=[O:22])[C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=3)=[C:10]([O:13][CH3:14])[CH:11]=2)[CH2:6][CH2:5]1)=[O:25]

Participants

4

Reactant 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 23457890HCID 23457890, compound

Product 1

HCID 54224008HCID 54224008, compound

Procedure

Analogously to the description in Example 2, 0.4 g of 1-methyl-5-benzoyl-6-methoxy-indane-1-carboxylic acid methyl ester and 5 ml of 2 N sodium hydroxide solution in 15 ml of methanol give 1-methyl-5-benzoyl-6-methoxy-indane-1-carboxylic acid of melting point 135°-137° C (from ether-petroleum ether). The starting material can be obtained as follows:

Sources & evidence

ORD record
ord-378b010feb4445c7ba205502c4182090
Source dataset
uspto-grants-1977_11
Patent number
US04057573

Reaction notes

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