2-Amino-4-methylbenzothiazole → HCID 21399909, compound

HRID 1438974Notes

Reaction equation

HRID 1438974 reaction equation
[CH3:1][O:2][C:3]([N:5]=[C:6]=[O:7])=[O:4].[NH2:8][C:9]1[S:10][C:11]2[CH:17]=[CH:16][CH:15]=[C:14]([CH3:18])[C:12]=2[N:13]=1>C(Cl)Cl>[CH3:18][C:14]1[C:12]2[N:13]=[C:9]([NH:8][C:6](=[O:7])[NH:5][C:3]([O:2][CH3:1])=[O:4])[S:10][C:11]=2[CH:17]=[CH:16][CH:15]=1

Participants

4

Reactant 2

HCID 151322-Amino-4-methylbenzothiazoleHCID 4156749Methyl isocyanatoformate

Product 1

HCID 21399909HCID 21399909, compoundYield 37%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Two and one half parts by weight of methoxycarbonyl isocyanate was added gradually with stirring to a solution of 4 parts by weight of 2-amino-4-methylbenzothiazole dissolved in 250 parts by weight of methylene chloride. The reaction mixture was stirred at room temperature for 12 hours. The solution was concentrated to one fifth the original volume and the solid isolated by filtration to give a 37% yield of methyl 4-(4-methylbenzothiazol-2-yl)allophanate having a melting point of 272°-280° with decomposition.

Workup

  1. concentrationThe solution was concentrated to one fifth the original volume
  2. customthe solid isolated by filtration

Sources & evidence

ORD record
ord-15d4199792ac4a369e4b940efa4c0e8e
Source dataset
uspto-grants-1977_11
Patent number
US04057638

Reaction notes

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