HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → Methyl 4-(5-chloro-4-methylbenzothiazol-2-yl)allophanate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | 5-Chloro-4-methyl-1,3-benzothiazol-2-amine | HCID 1180481 | — |
| Reactant | Methyl isocyanatoformate | HCID 4156749 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Methyl 4-(5-chloro-4-methylbenzothiazol-2-yl)allophanate | HCID 21399912 | 40% |
Reaction Steps
A solution of 2 parts by weight of methoxycarbonylisocyanate in 15 parts by weight of methylene chloride was added gradually with stirring to a solution, at room temperature, of 4 parts by weight of 2-amino-5-chloro-4-methylbenzothiazole in 75 parts by weight of methylene chloride and 50 parts by weight of tetrahydrofuran. After stirring the reaction mixture at room temprature overnight, a product was isolated by filtration giving a 40% yield of methyl 4-(5-chloro-4-methylbenzothiazol-2-yl)allophanate having a melting point greater than 275° .
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04057638 |
| Source dataset | uspto-grants-1977_11 |
| ORD ID | ord-bb8c8c72267340d39ef7c695b07815c1 |
| Source note | uspto-grants-1977_11 |