HCID 21399957, compound → HCID 21399963, compound

HRID 1438986Notes

Reaction equation

HRID 1438986 reaction equation
[CH3:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:14]=1[NH:13][C:12]1[CH:11]([C:15]([OH:17])=[O:16])[CH2:10][CH2:9][CH2:8][C:7]2=1>C1(C(C)C)C=CC=CC=1.[C].[Pd]>[CH3:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:14]=1[NH:13][C:12]1[C:11]([C:15]([OH:17])=[O:16])=[CH:10][CH:9]=[CH:8][C:7]2=1

Participants

4

Reactant 1

HCID 21399957HCID 21399957, compound

Product 1

HCID 21399963HCID 21399963, compoundYield 75%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 7406CumeneSolvent

Procedure

The ethyl ester of 8-methyl-1,2,3,4-tetrahydrocarbazole-1-carboxylic acid is dissolved in cumene and, after adding 10% palladium-carbon, dehydrogenated as set forth in Example 1(b). After recrystallization from methanol, the ethyl ester of 8-methylcarbazole-1-carboxylic acid is obtained in a 75% yield, m.p. 68° C.

Workup

  1. customAfter recrystallization from methanol

Sources & evidence

ORD record
ord-7a7dc23bfdff4865a8123a64da03b02f
Source dataset
uspto-grants-1977_11
Patent number
US04057640

Reaction notes

Loading…