Ammonia → HCID 54208357, compound

HRID 1438990Notes

Reaction equation

HRID 1438990 reaction equation
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.N.[CH3:8][C:9]1[C:21]([CH3:22])=[C:20]2[C:12]([C:13]3[CH:14]=[CH:15][CH:16]=[C:17]([C:23](O)=[O:24])[C:18]=3[NH:19]2)=[CH:11][CH:10]=1>>[CH3:8][C:9]1[C:21]([CH3:22])=[C:20]2[C:12]([C:13]3[CH:14]=[CH:15][CH:16]=[C:17]([C:23]([N:1]4[CH2:6][CH2:5][O:4][CH2:3][CH2:2]4)=[O:24])[C:18]=3[NH:19]2)=[CH:11][CH:10]=1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 8083MorpholineHCID 21399914HCID 21399914, compound

Product 1

HCID 54208357HCID 54208357, compoundYield 75%

Procedure

Under the conditions of Example 31, but with the difference that excess morpholine is added to the reaction mixture in place of the ammonia, 7,8-dimethylcarbazole-1-carboxylic acid is converted into the carboxylic acid morpholide. After recrystallization from dioxane -- water, 7,8-dimethylcarbazole-1-carboxylic acid morpholide is obtained in a 75% yield, m.p. 183° C.

Workup

  1. customAfter recrystallization from dioxane

Sources & evidence

ORD record
ord-795cdc998951482ea22b15398dd5112f
Source dataset
uspto-grants-1977_11
Patent number
US04057640

Reaction notes

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