HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-5-methylbenzoic acid → 3-Methyl-5,6,7,8-tetrahydrocarbazole-1-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-5-methylbenzoic acid | HCID 76255 | — |
| Reactant | 2-Bromocyclohexanone | HCID 11789758 | — |
| Product | 3-Methyl-5,6,7,8-tetrahydrocarbazole-1-carboxylic acid | HCID 11775987 | 55% |
Reaction Steps
Under the conditions of Example 60, 2-bromocyclohexanone is reacted with the methyl ester of 2-amino-5-methylbenzoic acid; after recrystallization from cyclohexane, the methyl ester of 3-methyl-5,6,7,8-tetrahydrocarbazole-1-carboxylic acid is obtained in a 55% yield, m.p. 111° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04057640 |
| Source dataset | uspto-grants-1977_11 |
| ORD ID | ord-5cc3a8ad73984bc0b946d285119916ad |
| Source note | uspto-grants-1977_11 |