HCID 12383924, compound → HCID 3049083, compound

HRID 1439015Notes

Reaction equation

HRID 1439015 reaction equation
[H-].[Al+3].[Li+].[H-].[H-].[H-].[CH2:7]([C:10]([NH:17][CH2:18][CH2:19][C:20](OC)=[O:21])([CH2:14][CH2:15][CH3:16])[CH2:11][CH2:12][CH3:13])[CH2:8][CH3:9]>CCOCC>[OH:21][CH2:20][CH2:19][CH2:18][NH:17][C:10]([CH2:7][CH2:8][CH3:9])([CH2:14][CH2:15][CH3:16])[CH2:11][CH2:12][CH3:13]

Participants

4

Reactant 2

HCID 12383924HCID 12383924, compoundHCID 21226445Aluminium lithium hydride

Product 1

HCID 3049083HCID 3049083, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Into a 500-ml three-necked flask fitted with a mechanical stirrer, a condenser and a dropping-funnel were introduced 3.8 g (0.17 mol) of lithium aluminium hydride and 130 ml of dry ether. To this mixture were slowly added 12.2 g (0.05 mol) of methyl 3-(1,1-di-n-propyl-n-butylamino)-propanoate, prepared as previously described. The reaction medium was heated under reflux for 12 hours and then hydrolyzed. The precipitate which formed was washed with ether, the ether was evaporated off and the oil so obtained was distilled.

Workup

  1. customInto a 500-ml three-necked flask fitted with a mechanical stirrer, a condenser and a dropping-funnel
  2. customprepared
  3. temperatureThe reaction medium was heated
  4. temperatureunder reflux for 12 hours
  5. customThe precipitate which formed
  6. washwas washed with ether
  7. customthe ether was evaporated off
  8. customthe oil so obtained
  9. distillationwas distilled

Sources & evidence

ORD record
ord-a83faf34bc6a427db098ca52d8bc2193
Source dataset
uspto-grants-1977_11
Patent number
US04057644

Reaction notes

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