Pyridine → HCID 70590126, compound

HRID 1439024Notes

Reaction equation

HRID 1439024 reaction equation
[CH3:1][C:2]1[C:7]([OH:8])=[C:6]([CH2:9][OH:10])[C:5]([CH2:11][Cl:12])=[CH:4][N:3]=1.C(Cl)(Cl)Cl.N1C=CC=CC=1.[C:23](Cl)(Cl)=[O:24]>C1C=CC=CC=1>[ClH:12].[Cl:12][CH2:11][C:5]1[CH:4]=[N:3][C:2]([CH3:1])=[C:7]2[O:8][C:23](=[O:24])[O:10][CH2:9][C:6]=12

Participants

6

Reactant 4

HCID 1049PyridineHCID 6212ChloroformHCID 6371PhosgeneHCID 2031304-Pyridinemethanol, 5-chloromethyl-3-hydroxy-2-methyl-

Product 1

HCID 70590126HCID 70590126, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

To a solution of 0.01 mole of 2-methyl-3-hydroxy-4-hydroxymethyl-5-chloromethylpyridine in 50 ml. chloroform and 50 ml. of pyridine is added at 0°-5° C. a solution of 0.011 mole of phosgene in benzene. The mixture is allowed to warm to room temperature and is stirred overnight. The mixture is then concentrated in vacuo and excess saturated sodium bicarbonate solution is added. The precipitate is collected on a filter and sucked dry.

Workup

  1. concentrationThe mixture is then concentrated in vacuo and excess saturated sodium bicarbonate solution
  2. additionis added
  3. customThe precipitate is collected on
  4. filtrationa filter
  5. customsucked dry

Sources & evidence

ORD record
ord-33391af544ac434a84f8a4273eb30a9c
Source dataset
uspto-grants-1977_11
Patent number
US04057637

Reaction notes

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