HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfuric Acid → 3-(3',4'-Dichloro-4-biphenylyl)-3-hydroxybutyric acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Ethyl bromoacetate | HCID 7748 | — |
| Reactant | 1-[4-(3,4-Dichlorophenyl)phenyl]ethan-1-one | HCID 16768815 | — |
| Catalyst | Zinc | HCID 23994 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 3-(3',4'-Dichloro-4-biphenylyl)-3-hydroxybutyric acid ethyl ester | HCID 54412284 | — |
Reaction Steps
A mixture of 20 g. of ethyl bromoacetate, 26.5 g. of 4-acetyl-3',4'-dichlorobiphenyl and 8 lg. of zinc foil is added to 100 ml. of benzene and the mixture is stirred and heated under reflux for one hour. It is cooled and dilute sulfuric acid is added to decompose the alcoholate obtained. The organic phase is separated off and, after the customary work up, 3-(3',4'-dichloro-4-biphenylyl)-3-hydroxybutyric acid ethyl ester is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04057647 |
| Source dataset | uspto-grants-1977_11 |
| ORD ID | ord-41f8819fea85400fad2abe0b64f6da35 |
| Source note | uspto-grants-1977_11 |