3-(2',4'-Difluoro-4-biphenylyl)-2-butenoic acid methyl ester → HCID 53956120, compound

HRID 1439046Notes

Reaction equation

HRID 1439046 reaction equation
[CH3:1][O:2][C:3](=[O:21])[CH:4]=[C:5]([C:7]1[CH:12]=[CH:11][C:10]([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][C:14]=2[F:20])=[CH:9][CH:8]=1)[CH3:6]>[Pd].C(O)C>[CH3:1][O:2][C:3](=[O:21])[CH2:4][CH:5]([C:7]1[CH:8]=[CH:9][C:10]([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][C:14]=2[F:20])=[CH:11][CH:12]=1)[CH3:6]

Participants

4

Reactant 1

HCID 536963323-(2',4'-Difluoro-4-biphenylyl)-2-butenoic acid methyl ester

Product 1

HCID 53956120HCID 53956120, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

1 g. of 3-(2'4'-difluoro-4-biphenylyl)-2-butenoic acid methyl ester in 20 ml. of ethanol is hydrogenated on 0.1 g. of 5% Pd-C under 1 atmosphere at 20° until the reaction has ceased. The mixture is filtered and the filtrate is evaporated to give 3-(2',4'-difluoro-4-biphenylyl)butyric acid methyl ester.

Workup

  1. customat 20°
  2. filtrationThe mixture is filtered
  3. customthe filtrate is evaporated

Sources & evidence

ORD record
ord-c354d3e91569421e88a1a81f89a72539
Source dataset
uspto-grants-1977_11
Patent number
US04057647

Reaction notes

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