HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-(2',4'-Difluoro-4-biphenylyl)butyric acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ethyl Acetoacetate | HCID 8868 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 4'-(1-Bromoethyl)-2,4-difluoro-1,1'-biphenyl | HCID 21322621 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-(2',4'-Difluoro-4-biphenylyl)butyric acid | HCID 21322540 | — |
Reaction Steps
1 g. of 2-[1-(2',4'-biphenylyl)ethyl]butan-3-one acid ethyl ester, obtained by reacting 4-(1-bromoethyl)-2',4'-difluorobiphenyl with ethyl acetoacetate, and 15 ml. of 50% KOH are stirred for 45 minutes at 40° under N2. The mixture is cooled, diluted with water and brought to pH 10 with HCl. The reaction mixture is washed with ether and worked up in the customary manner to give 3-(2',4'-difluoro-4-biphenylyl)butyric acid, m.p. 109°-110°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04057647 |
| Source dataset | uspto-grants-1977_11 |
| ORD ID | ord-5ba17ed31f5741b0a3abb34add3fc2ae |
| Source note | uspto-grants-1977_11 |