HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 3-(2',4'-Difluoro-4-biphenylyl)butane-1,3-diol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 1-Acetoxy-3-(2',4'-difluoro-4-biphenylyl)-3-butanol | HCID 21322561 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-(2',4'-Difluoro-4-biphenylyl)butane-1,3-diol | HCID 21322562 | — |
Reaction Steps
A solution of 3.2 g. of 1 -acetoxy-3-(2',4'-difluoro-4-biphenylyl)-3-butanol and 2 g. of NaOH in 30 ml. of 80% aqueous ethanol is heated under reflux for 3 hours. Water is added; the product is extracted with chloroform, and the extract is evaporated to give 3-(2',4'-difluoro-4-biphenylyl)butane-1,3-diol, m.p. 82°-84°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04057647 |
| Source dataset | uspto-grants-1977_11 |
| ORD ID | ord-ee7a2515f91b4c87b8a3bf0040658df7 |
| Source note | uspto-grants-1977_11 |