HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 3-(2',4'-Difluoro-4-biphenylyl)butane-1,3-diol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 3-Acetoxy-3-(2',4'-difluoro-4-biphenylyl)butan-1-ol | HCID 21322626 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 3-(2',4'-Difluoro-4-biphenylyl)butane-1,3-diol | HCID 21322562 | — |
Reaction Steps
3.20 g. of 3-acetoxy-3-(2',4'-difluoro-4-biphenylyl)butan-1-ol and 2 g. of KOH in 50 ml. of methanol are heated under reflux for 2 hours. Water and chloroform are added and the reaction mixture is worked up to give 3(2',4'-difluoro-4-biphenylyl)butane-1,3-diol, m.p. 82°-84°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04057647 |
| Source dataset | uspto-grants-1977_11 |
| ORD ID | ord-475c675664d84c2d9f0fd834e03661ea |
| Source note | uspto-grants-1977_11 |