HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-(2',4'-Difluoro-4-biphenylyl)butyric acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Ethyl chloroformate | HCID 10928 | — |
| Reactant | 2,4-Difluoro-1,1'-biphenyl | HCID 169974 | — |
| Product | 3-(2',4'-Difluoro-4-biphenylyl)butyric acid | HCID 21322540 | — |
Reaction Steps
Grignard solution, prepared from 3.11 g. of 4-(1-bromo-2-propyl)-2-propyl)-2',4'-difluorobiphenyl, in 40 ml. of THF is added slowly to a solution of 1.2 g. of ethyl chloroformate in 20 ml. of THF. 15 ml. of concentrated hydrochloric acid are added. The mixture is heated under reflux for 24 hours and worked up in the customary manner to give 3-(2',4'-difluoro-4-biphenylyl)butyric acid, m.p. 109°-110°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04057647 |
| Source dataset | uspto-grants-1977_11 |
| ORD ID | ord-af3d4b56492742078bb7b93146088e67 |
| Source note | uspto-grants-1977_11 |