HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 3-(2',4'-Difluoro-4-biphenylyl)butane-1,3-diol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | 1-(2',4'-Difluoro(1,1'-biphenyl)-4-yl)ethan-1-one | HCID 104542 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | HCID 178467894 | HCID 178467894 | — |
| Product | 3-(2',4'-Difluoro-4-biphenylyl)butane-1,3-diol | HCID 21322562 | — |
Reaction Steps
A solution of 2.76 g. of 3 hydroxy-3-(2',4'-difluoro-4-biphenylyl)-butanol, obtained by reacting 4-acetyl-2',4'-difluorobiphenyl with 2,2-diethoxyethyl magnesium bromide and subsequently hydrolyzing the reaction product, in 12 ml. of ethanol is added dropwise to a solution of 0.6 g. of NaBH4 in 15 ml. of ethanol. The mixture is stirred for 2 hours at 20° and worked up in the customary manner to give 3-(2',4'-difluoro-4-biphenylyl)butane-1,3-diol, m.p. 82°-84°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04057647 |
| Source dataset | uspto-grants-1977_11 |
| ORD ID | ord-569fe492d333421c9a37b2aa45849eea |
| Source note | uspto-grants-1977_11 |