3-(2',4'-Difluoro-4-biphenylyl)butane-1,3-diol → 3-(2',4'-Difluoro-4-biphenylyl)butan-1-ol

HRID 1439073Notes

Reaction equation

HRID 1439073 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][C:12]([C:15](O)([CH3:19])[CH2:16][CH2:17][OH:18])=[CH:11][CH:10]=1>[Pd].C(O)(=O)C>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][C:12]([CH:15]([CH3:19])[CH2:16][CH2:17][OH:18])=[CH:11][CH:10]=1

Participants

4

Reactant 1

HCID 213225623-(2',4'-Difluoro-4-biphenylyl)butane-1,3-diol

Product 1

HCID 213226043-(2',4'-Difluoro-4-biphenylyl)butan-1-ol

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 176Acetic AcidSolvent

Procedure

2.78 g. of 3-(2',4'-difluoro-4-biphenylyl)butane-1,3-diol are dissolved in 30 ml. of acetic acid and hydrogenated at 20° and under 1 atmosphere on 0.5 g of 10% Pd-C until the reaction has ceased. Filtering and evaporating gives 3-(2',4'-difluoro-4-biphenylyl)butan-1-ol.

Workup

  1. customhydrogenated at 20°
  2. filtrationFiltering
  3. customevaporating

Sources & evidence

ORD record
ord-e1326e65f9fb413cbfa65d8fe3eba983
Source dataset
uspto-grants-1977_11
Patent number
US04057647

Reaction notes

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