1,3-Propanediamine → HCID 21398412, compound

HRID 1439177Notes

Reaction equation

HRID 1439177 reaction equation
[C:1]([C:4]1[CH:12]=[CH:11][CH:10]=[CH:9][C:5]=1[C:6]([OH:8])=O)(=O)[CH3:2].[CH2:13]([NH2:17])[CH2:14][CH2:15][NH2:16]>>[CH3:2][C:1]12[NH:17][CH2:13][CH2:14][CH2:15][N:16]1[C:6](=[O:8])[C:5]1[C:4]2=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

3

Reactant 2

HCID 4281,3-PropanediamineHCID 684742-Acetylbenzoic acid

Product 1

HCID 21398412HCID 21398412, compound

Procedure

16.4 Parts of o-acetyl-benzoic acid and 8 parts of 1,3-propanediamine are heated for 2 hours at 150°-160°. The reaction mixture is then distilled under high vacuum. The 10b-methyl-1,3,4,10b-tetrahydro-pyrimido[2,1-a]isoindol -6(2H)-one obtained of the formula ##STR35## boils at 120°-123°/0.1 Torr. After recrystallising from ethyl acetate/benzine, it melts at 64.5°. The following compounds are obtained in an analogous manner:

Workup

  1. distillationThe reaction mixture is then distilled under high vacuum

Sources & evidence

ORD record
ord-4aa509b8e1524f548efd1abc75367842
Source dataset
uspto-grants-1977_11
Patent number
US04058529

Reaction notes

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