tert-Butyl isocyanate → HCID 86735196, compound

HRID 1439187Notes

Reaction equation

HRID 1439187 reaction equation
[OH:1][CH2:2][C@@:3]12[C@@H:20]3[C:11]([C@H:12]4[C@@:16]([CH2:18][CH2:19]3)([CH3:17])[C@@H:15]([O:21][C:22](=[O:27])[C:23]([CH3:26])([CH3:25])[CH3:24])[CH2:14][CH2:13]4)=[CH:10][CH2:9][C:8]1=[CH:7][C:6](=[O:28])[CH2:5][CH2:4]2.[C:29]([N:33]=[C:34]=[O:35])([CH3:32])([CH3:31])[CH3:30]>CCCCCC>[OH:1][CH2:2][C@@:3]12[C@@H:20]3[C:11]([C@H:12]4[C@@:16]([CH2:18][CH2:19]3)([CH3:17])[C@@H:15]([O:21][C:22](=[O:27])[C:23]([CH3:25])([CH3:24])[CH3:26])[CH2:14][CH2:13]4)=[CH:10][CH2:9][C:8]1=[CH:7][C:6](=[O:28])[CH2:5][CH2:4]2.[C:29]([NH:33][C:34](=[O:1])[O-:35])([CH3:32])([CH3:31])[CH3:30]

Participants

4

Reactant 2

HCID 62412tert-Butyl isocyanateHCID 22800129HCID 22800129, compound

Product 1

HCID 86735196HCID 86735196, compound

Reagents, catalysts & solvents 1

HCID 8058HexaneSolvent

Procedure

A mixture of 1.5 g. of 19-hydroxy-17β-pivaloxyandrosta-4,7-dien-3-one and 22.5 ml. of t-butylisocyanate was heated at 95°-100° C. under nitrogen for two days, whereupon 45 ml. of hexane was added and the mixture was concentrated. Subsequent filtration yielded 19-hydroxy-17β-pivaloxyandrosta-4,7-dien-3-one N-t-butylcarbamate, mp 163°-167° C.

Workup

  1. additionA mixture of 1.5 g
  2. concentrationthe mixture was concentrated
  3. filtrationSubsequent filtration

Sources & evidence

ORD record
ord-65b06894b61d4f249f2c06357598b7d3
Source dataset
uspto-grants-1977_11
Patent number
US04058539

Reaction notes

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