Acetyl chloride → HCID 86735199, compound

HRID 1439245Notes

Reaction equation

[CH2:1]([N:3]1[C:12](=[O:13])[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([C:14]([OH:23])([C:19]([F:22])([F:21])[F:20])[C:15]([F:18])([F:17])[F:16])[CH:10]=2)[NH:5][C:4]1=[O:24])[CH3:2].[C:25](Cl)(=[O:27])[CH3:26]>>[CH2:1]([N:3]1[C:12](=[O:13])[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([C:14]([O:23][C:25](=[O:27])[CH3:26])([C:19]([F:22])([F:20])[F:21])[C:15]([F:16])([F:17])[F:18])[CH:10]=2)[NH:5][C:4]1=[O:24])[CH3:2]

Participants

Reactant 2

HCID 6367Acetyl chloride

HCID 21398897HCID 21398897, compound

Product 1

HCID 86735199HCID 86735199, compound

Procedure

Reaction of the compounds of formula I wherein Z is hydroxy with the appropriate acid chloride affords the corresponding alkanoyloxy derivative. For instance, reaction of 3-ethyl-6-(hexafluoro-2-hydroxy-2-propyl)quinazoline-2,4-dione with acetyl chloride yields 3-ethyl-6-(2-acetoxyhexafluoro-2-propyl)quinazoline-2,4-dione.

Sources & evidence

ORD record: ord-a3dcae0ba32b40afaa7c92a8859cdf28
Source dataset: uspto-grants-1977_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04058612

Reaction notes

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