Methyl chloroacetate → HCID 19900755, compound

Participants

Reaction Steps

The compound is prepared analogously to Example 10 by saponification of the crude methyl ester of (3-bromo-2-thienylthio-acetic acid prepared with a 76% yield from 2,3-dibromothiophene, butyllithium, sulfur, and methyl chloroacetate. After chromatography on silica gel (eluent: hexane/acetone/acetic acid = 93:5:2), the product is obtained as a non-crystallizing oil. The compound shows the physiochemical data to be expected (IR, NMR spectrum) and yields correct elementary analyses for C, H, S, and Br.

Provenance & Evidence