HuagongsheHuagongshe Chemistry Print Report · For research reference only
Glycerol → 2,3-Dihydroxypropyl 4-(n-hexadecylamino)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Glycerol | HCID 753 | — |
| Reactant | Boron trifluoride etherate | HCID 8000 | — |
| Reactant | 4-(Hexadecylamino)benzoic acid | HCID 47263 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 2,3-Dihydroxypropyl 4-(n-hexadecylamino)benzoate | HCID 13019380 | — |
Reaction Steps
A solution of 11.8 g of 4-(n-hexadecylamino)benzoic acid, 1.00 g of glycerol, and 5.35 ml of boron trifluoride etherate in 200 ml of toluene is stirred under reflux for 48 hours. The solution is treated with an additional 5.35 ml of boron trifluoride etherate and refluxing is continued for 120 hours. Dilution with water and methylene chloride followed by filtration affords 2,3-dihydroxypropyl 4-(n-hexadecylamino)benzoate as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04058550 |
| Source dataset | uspto-grants-1977_11 |
| ORD ID | ord-10ba85f9cd0544bd84d92687c509d89d |
| Source note | uspto-grants-1977_11 |